Technology
Ageing muscles trade strength to limit cell damage
The Hindu BusinessLine·
University of Copenhagen researchers found ageing muscles shift toward slow-twitch fibres as cardiolipin levels fall in mitochondria, limiting strength to shield cells from damage. In mice, restoring cardiolipin to about two-thirds of normal reversed muscle wasting and prevented early death, the ScienceDaily report said. Assistant Professor Fabian Finger said the fibre switch trades power for protection.
Prism
What It Means For You
- Older adults with sarcopenia may eventually see therapies targeting mitochondrial cardiolipin if human trials follow the mouse findings.
- Copenhagen scientists tied low cardiolipin to slow-twitch fibre shifts and excess reactive oxygen species.
- Restoring two-thirds of cardiolipin in mice reversed wasting and prevented early death.
What's Happening
- Copenhagen scientists tied low cardiolipin to slow-twitch fibre shifts and excess reactive oxygen species.
- Restoring two-thirds of cardiolipin in mice reversed wasting and prevented early death.
- Finger said antioxidant treatment worsened mice when it blocked reactive oxygen signals that trigger protective fibre switching.
Cardiolipin in muscle mitochondria
- Finger said antioxidant treatment worsened mice when it blocked reactive oxygen signals that trigger protective fibre switching.
- Copenhagen scientists tied low cardiolipin to slow-twitch fibre shifts and excess reactive oxygen species.
- Restoring two-thirds of cardiolipin in mice reversed wasting and prevented early death.
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